Endocrine Abstracts

Medical plants believed to be safe and cost effective than synthetic hypoglycaemic agents play important roles in the management of diabetes mellitus in developing countries where resources are meagre. We have isolated triterpenes from Syzygium aromaticum as the bioactive compounds that possesses hypoglycaemic effects in experimental diabetes. However, the poor water solubility of triterpenes observed in oral administration has necess...

Medical plants believed to be safe and cost effective than synthetic hypoglycaemic agents play important roles in the management of diabetes mellitus in developing countries where resources are meagre. We have isolated triterpenes from Syzygium aromaticum as the bioactive compounds that possesses hypoglycaemic effects in experimental diabetes. However, the poor water solubility of triterpenes observed in oral administration has necess...

Investigations conducted in our laboratory have shown that transdermal delivery of insulin has several potential advantages over the conventional route. These pectin-insulin (PI)-containing dermal patches possess the ability to maintain sustained controlled release of insulin into the bloodstream of streptozotocin-induced diabetic rats with concomitant reduction of blood glucose levels. We have successfully formulated and optimized the concoction of the PI-containing dermal pa...

The tight glycaemic control in type 1 diabetes which requires uncomfortable multiple insulin injections is associated with patients’ non-compliance. Therefore, methods which can sustain therapeutic controlled insulin release into the blood based on topical applications may be beneficial with glycaemic control. Accordingly, the present study investigated whether topically applied pectin insulin (PI) amidated matrix patch sustains insulin release into the bloodstream and co...

The magnitude and duration of postprandial blood glucose elevations due to hydrolysis of carbohydrates are major risk factors of diabetes and coronary heart diseases. Inhibition of the key carbohydrate hydrolyzing enzymes in the small intestine suppresses postprandial blood glucose peaks and reduces chronic vascular complications in diabetic subjects. Recent reports indicate that Syzygium spp-derived oleanolic acid (OA) inhibits glucose transport in the small intestin...